MBNMAdose - Dose-Response MBNMA Models

Fits Bayesian dose-response model-based network meta-analysis (MBNMA) that incorporate multiple doses within an agent by modelling different dose-response functions, as described by Mawdsley et al. (2016) <doi:10.1002/psp4.12091>. By modelling dose-response relationships this can connect networks of evidence that might otherwise be disconnected, and can improve precision on treatment estimates. Several common dose-response functions are provided; others may be added by the user. Various characteristics and assumptions can be flexibly added to the models, such as shared class effects. The consistency of direct and indirect evidence in the network can be assessed using unrelated mean effects models and/or by node-splitting at the treatment level.

Last updated 5 months ago

4.91 score 10 stars 27 scripts 310 downloads

MBNMAtime - Run Time-Course Model-Based Network Meta-Analysis (MBNMA) Models

Fits Bayesian time-course models for model-based network meta-analysis (MBNMA) that allows inclusion of multiple time-points from studies. Repeated measures over time are accounted for within studies by applying different time-course functions, following the method of Pedder et al. (2019) <doi:10.1002/jrsm.1351>. The method allows synthesis of studies with multiple follow-up measurements that can account for time-course for a single or multiple treatment comparisons. Several general time-course functions are provided; others may be added by the user. Various characteristics can be flexibly added to the models, such as correlation between time points and shared class effects. The consistency of direct and indirect evidence in the network can be assessed using unrelated mean effects models and/or by node-splitting.

Last updated 5 months ago

4.12 score 6 stars 22 scripts 317 downloads